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"Make a mess" and "make a mess of..."

"Make a mess" and "make a mess of..."

Hi, dear friends!
Studing Make Collocation i understand that the meaning of these two combination of words is not the same. The first one is connected to the state of disoderliness and the second one means any damage. For the second case i know that there is an idiom. But i don't understand has "make a mess of" its idiomatic meaning right along? If yes, then is "of" any sign of this idiom? Or may be, as usual there is a lot of exceptions and contexts in any language. Could anybody explain me? Thanks. Tatyana